TeraView Demonstrates Capability for On-line Tablet Inspection
TeraView uses its years of experience working with the pharmaceutical industry and its proprietary terahertz platform to demonstrate real time measurements of tablet coating thickness and other critical quality attributes of solid dosage forms.
TeraView, the pioneer and leader in terahertz solutions and technology for the pharmaceutical and life science industry, announces that it has conducted successful proof of principle for high speed measurements of coating thickness on tablets applicable to on-line tablet inspection. The non-contact, non-destructive technique may also be extended to on-line measurement of other key product attributes, such as coating or core density tablets delamination and many other parameters characterising the performance of drugs which TeraView has identified with its products and collaborators.
TeraView’s most recent innovation represents an important step forward addressing one of the most difficult problems to be overcome in on-line pharmaceutical inspection; namely measuring product attributes like coating thickness accurately and rapidly while the tablets are in random motion in a coating pan. This capability opens up the opportunity for deployment of terahertz sensors in rapid, non-destructive tablet inspection to ensure that pharmaceutical products remain within the specifications necessary to ensure therapeutic efficacy and drug performance. Ultimately, such sensors could also be used in feedback systems to control production parameters (e.g. coating spray rates, tablet compression force for single and multiple layer tablets) in real time. This technique could also support the pharmaceutical industry’s future plans to implement continuous process systems in drug manufacture.
When combined with TeraView’s existing multiple sensor platforms and strong, proprietary applications know-how, this innovation greatly enhances the Company’s intellectual property base in the pharmaceutical area to provide complete solutions to meet customer needs.
TeraView is now actively exploring on-line deployment through prototype development with its existing customer base, and welcomes discussions with other interested parties.
Paddy O’Kelly, Chief Operating Officer of TeraView commented: “This initial demonstration is a natural extension of our terahertz sensors developed for other industries as well as our analytical know-how cultivated in close collaboration with the pharmaceutical industry and the regulators over the past few years. This is another world first for TeraView”.
Dr Don Arnone, Chief Executive Officer of TeraView added: “This study is exciting news for our pharmaceutical customers. It enables us to provide Terahertz solutions to address their business issues from early stage product development all the way through to assuring product performance during manufacture. It is also good news for the Company because it has the potential to expand our footprint in the pharmaceutical manufacturing market in the future.
TeraView’s proprietary platform uses the terahertz spectrum between light and radio waves and offers the advantage of being non-invasive and non-destructive. Past studies have demonstrated how terahertz uniquely provides 3 dimensional and chemical information on the contents of tablets and capsules normally invisible to conventional techniques.
Note for editors
Previous studies, including the FDA’s “Delayed Release Tablet Dissolution Related To Coating Thickness By Terahertz Pulsed Image Mapping” have been published in the Journal of Pharmaceutical Sciences and other leading pharmaceutical journals.
Terahertz light is unique in its ability to non-destructively image tablets and other dosage forms. X-ray and infrared frequently lack sensitivity or penetration and cannot produce such images without first destroying the tablet. TeraView currently works closely with blue chip customers in the pharmaceutical industry who are exploring the use of terahertz in product and process development and quality control of finished product in manufacturing.