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Major Pharmaceutical Company Uses Terahertz Pulsed Imaging for Analysis of Layer Separation in Tablets

May 21, 2013


Leading scientists at Takeda Pharmaceutical Company conducted groundbreaking quality control University of Arkansasresearch of layer separation of pharmaceutical tablets using Terahertz Pulsed Imaging (TPI™). Data collection and findings are based on their use of TeraView’s TPI imaga 2000 system and are published in the International Journal of Pharmaceutics.

The research, Quantitative analysis of the layer separation risk in bilayer tablets using terahertz pulsed imaging, compares Terahertz Pulsed Imaging technique to other analytical methods and has determined that “TPI can aid in quality control by providing a precise estimate of the layer separation risk and robust quality of bilayer tablet development with better understanding of layer separation”.

In recent months, Terahertz Pulsed Imaging has received significant attention from the pharmaceutical research community with papers focusing the attention on the use of technique in the measurement and quality control of pharmaceutical coatings. TPI™ provides the ability to non-destructively and rapidly analyze the coating layer thickness and quality of coated pharmaceutical tablets and other solid dosage forms. Because it is non-destructive, tablets can be re-examined at later times to monitor coating stability or used for further functional studies with prior knowledge of the coating uniformity. Some of the recent papers include:

  • Critical factors in the measurement of tablet film coatings using terahertz pulsed imaging
  • Hardness and density distributions of pharmaceutical tablets measured by terahertz pulsed imaging
  • Terahertz pulsed imaging as an advanced characterisation tool for film coatings—A review


About Terahertz

Terahertz light lies between infra red and microwaves, and as such has unique properties which enables it to pass through objects and to transmit images and compositional (spectroscopic) information that is ordinarily hidden. Terahertz is non destructive, safe and fast, making it the ideal inspection and imaging modality for many applications across a range of industries. TeraView has demonstrated the potential of terahertz technology in a number of applications including the detection of hidden weapons and explosives in security screening, monitoring the quality of pharmaceutical drugs, high value coatings used in automotive and other industries, as well as medical imaging of cancer.

About TeraView

TeraView is the world’s first and leading company solely focused upon the application of terahertz light to provide solutions to customer issues. A spin out from the Toshiba Corporation and Cambridge University, TeraView has developed its proprietary technology across a number of markets. These include fault analysis and quality assurance for semiconductor chips used in mobile computing and communications, as well as non destructive inspection of high value coatings used in the automotive, pharmaceutical, food and solar industries. With the largest number of systems in the field, as well as applications know-how made available to customers via a team of dedicated scientists using intellectual property and knowledge in peer-reviewed scientific publications, TeraView is uniquely placed to deliver the business benefits of terahertz to customers. Headquartered in Cambridge UK, sales and customer support are available throughout the Far East, North America and Europe either directly or through a network of distributors.