Concentration analysis of breast tissue phantoms with terahertz spectroscopy
Truong, Bao CQ, Anthony J. Fitzgerald, Shuting Fan, and Vincent P. Wallace. “Concentration analysis of breast tissue phantoms with terahertz spectroscopy.” Biomedical optics express 9, no. 3 (2018): 1334-1349.
Terahertz imaging has been previously shown to be capable of distinguishing normal breast tissue from its cancerous form, indicating its applicability to breast conserving surgery. The heterogeneous composition of breast tissue is among the main challenges to progressing this potential research towards a practical application. In this paper, two concentration analysis methods are proposed for analyzing phantoms mimicking breast tissue. The dielectric properties and the double Debye parameters were used to determine the phantom composition. The first method is wholly based on the conventional effective medium theory while the second one combines this theoretical model with empirical polynomial models. Through assessing the accuracy of these methods, their potential for application to quantifying breast tissue pathology was confirmed.
The group used “All terahertz time-domain spectroscopy measurements were conducted in reflection mode using a TeraPulse4000 system (TeraView Ltd, Cambridge, UK). The system produces THz pulses with a spectral range from 0.06 to 4 THz.”