Methanol-Water-Dependent Structural Changes of Regenerated Silk Fibroin Probed by Terahertz Spectroscopy

Wu, Xu, Xiaodong Wu, Bin Yang, Min Shao, and Guojin Feng.AbstractThe mechanism of β-sheet crystallization in silk fibroin remains unclear, due to the incomplete information of protein assembly and structural state. The emerging terahertz (THz) spectroscopy...

Experimental and Theoretical Study of Strong Low-Terahertz Absorption of Thymine

Zhang, W-D., A. Bykhovski, J. A. Deibel, and E. R. Brown.AbstractThe absorption coefficient of a nucleobase-thymine-in powder form was measured with terahertz spectroscopy in both frequency- and time-domain experiments. For frequencies below 3 THz, a strong signature...

Mathematical Modelling of Liquid Transport in Swelling Pharmaceutical Immediate Release Tablets

Markl, D., Yassin, S., Wilson, D. I., Goodwin, D. J., Anderson, A., Zeitler, J. A.AbstractOral dosage forms are an integral part of modern health care and account for the majority of drug delivery systems. Traditionally the analysis of the dissolution behaviour of a...

Characterization of the Pore Structure of Functionalized Calcium Carbonate Tablets by Terahertz Time-Domain Spectroscopy and X-Ray Computed Microtomography

Markl, D. ; Wang, P. ; Ridgway, C. ; Karttunen, A. P. ; Chakraborty, M. ; Bawuah, P. ; Zeitler, J. A.AbstractNovel excipients are entering the market to enhance the bioavailability of drug particles by having a high porosity and, thus, providing a rapid liquid uptake...

On the role of API in determining porosity, pore structure and bulk modulus of the skeletal material in pharmaceutical tablets formed with MCC excipient

Cathy Ridgway ; Prince Bawuah ; Daniel Markl ; J.Axel Zeitler ; Jarkko Ketolainen ; Kai-Erik Peiponen ; Patrick GaneAbstractThe physical properties and mechanical integrity of pharmaceutical tablets are of major importance when loading with active pharmaceutical...

Use of a handheld terahertz pulsed imaging device to differentiate benign and malignant breast tissue

M. Grootendorst ; A. Fitzgerald ; S. Brouwer de Koning ; A. Santaolalla ; A. Portieri ; M. Van Hemelrijck ; M. Young ; J. Owen ; M. Cariati ; M. Pepper ; V. Wallace ; S. Pinder ; A. Purushotham,AbstractSince nearly 20% of breast-conserving surgeries (BCS) require...