Terahertz pulse time-domain holography method for phase imaging of breast tissue
Balbekin, Nikolay S., Quentin Cassar, Olga A. Smolyanskaya, Maksim S. Kulya, Nikolay V. Petrov, Gaetan MacGrogan, Jean-Paul Guillet, Patrick Mounaix, and Valery V. Tuchin. “Terahertz pulse time-domain holography method for phase imaging of breast tissue.” In Quantitative Phase Imaging V, vol. 10887, p. 108870G. International Society for Optics and Photonics, 2019.
Pulse holographic imaging along with time-domain spectroscopy scan and tomographic techniques are of great interest. Since the advantages of holography are the lack of focusing optics and high spatial resolution, and, comparing with tomography, less computation cost for numerical reconstruction, this technique is preferable for the analysis of thin histological samples. In this work we have created the experimental scheme that involves measurement of diffraction pattern of the collimated THz pulse field spatial distribution at some distance behind the object in the time-domain mode, thus allowing reconstruction of amplitude and phase distribution at the object plane by numerical backpropagation of the wavefront in the spectral domain. In our experiment, we used a breast biopsy sample containing cancer tissues, we also performed numerical simulations accounting for experimental conditions to confirm the conceptual applicability of the reconstruction method.